If the test shows you have only one of these abnormal genes and no symptoms, your doctor will likely make the diagnosis of sickle cell trait. are screened for sickle cell disease, which affects 1 in 2,400 children, and 1 in 400 Black children. If the test shows you have two abnormal hemoglobin genes, your doctor will likely make an SCD diagnosis. Sickle cell disease (SCD) is a blood disorder in which misshapen or sickled red blood cells can clog blood vessels and cause complications such as stroke and blood vessel damage (including to the brain). This will help determine which condition you have. If the test is positive, your doctor will probably order a second test called hemoglobin electrophoresis. A positive test result may mean you have sickle cell trait or SCD. Such mutated or abnormal hemoglobin can create RBCs that are sickle-shaped, leading to SCD.Ī sickle cell test looks only for the presence of hemoglobin S, which causes SCD. Normal red blood cells are round and smooth in a child with sickle cell disease, red blood cells are hard, sticky and shaped like a crescent, or sickle. Hemoglobin is a protein that carries oxygen to all parts of the body. If one of the genes is altered or mutated, it can change how the hemoglobin behaves. Sickle cell disease is a genetic blood disorder that affects hemoglobin in red blood cells. This is the material that makes up your genes. Like all proteins, the “blueprint” for hemoglobin exists in your DNA. This substitution decreases the solubility of the HbS when deoxygenated, causing sickle erythrocytes that cause intravascular occlusion leading. It picks up oxygen in the lungs and delivers it to other tissues and organs throughout your body. Sickle cell disease (SCD) is a hemoglobinopathy characterized by mutation of the beta-globin chain caused by glutamic acid substituted by valine in the sixth codon, which results in the formation of the mutant sickle cell hemoglobin (HbS) allele s. Regular hemoglobin is a protein carried by RBCs. The lab tech who examines your blood sample will be looking for an abnormal form of hemoglobin called hemoglobin S.
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